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March 7, 2026Journal of The Royal Society InterfaceOpen Access

Injury-specific muscle regeneration: a computational blueprint for cellular and cytokine drivers

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Authors

MHMegan HaaseTCTien ComlekogluAPAlexa Petrucciani

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Overview

Computational analysis identifies unique regeneration pathways in muscle injuries, suggesting tailored therapies could improve recovery.

Key Points

  • The study aims to understand how different types of muscle injuries affect regeneration by examining cellular and cytokine interactions.
  • Extended a validated computational model for muscle fibre remodelling after CTX, FI, and EC injuries.
  • Validated the model against literature-derived regeneration metrics.
  • Analyzed cellular and cytokine contributions at various stages of recovery across injury types.
  • Each injury type triggers unique cellular and cytokine interactions affecting regeneration.
  • EC injury recovery relies mainly on HGF, VEGF-A, and SSC activity early on.
  • FI injuries depend on HGF with later contributions from TGF-β, TNF-α, MCP-1, and SSCs.
  • CTX injuries show early TGF-β involvement and later roles for SSCs, TNF-α, VEGF-A, and fibroblast dynamics.

Cite This Study

Haase et al. (2026) studied this question.

synapsesocial.com/papers/69abc1c65af8044f7a4eabeahttps://doi.org/10.1098/rsif.2025.0534
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