August 15, 2003Physiological Genomics

Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration

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Population

Injured hindlimb skeletal muscle model

Design

Preclinical

Authors

SGSean C. GoetschJohns Hopkins University THThomas J. HawkePiedmont Athens Regional TGTeresa D. GallardoUniversité Paris-Sud

Discussion

Member takes

Implication

Remains preclinical in animal models; leaves open translation to human muscle repair strategies.

Structured PICO

Population

Injured hindlimb skeletal muscle model

Intervention

Transcriptional profiling (high-density oligonucleotide array analysis, quantitative real-time RT-PCR, in situ hybridization)

Outcome

Cellular and molecular events characterizing stages of muscle injury and regenerationsurrogate

Muscle regeneration requires coordinated modulation of inflammatory responses, myogenic progenitor cells, growth factors, and the extracellular matrix, characterized by specific transcriptional profiles.

Cite This Study

Goetsch et al. (2003) studied this question.

synapsesocial.com/papers/6a6f92c2439bab0cabc2d7de https://doi.org/10.1152/physiolgenomics.00056.2003

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Ask AI

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Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider