Prospective study investigates plasma concentrations and sedation effects of chlordiazepoxide in ICU patients, suggesting limited reliability for treatment.
Poor correlation between doses, plasma concentrations, and clinical effects limits the ability to use cumulated doses and plasma concentrations to predict the risk of prolonged sedation and respiratory depression, making chlordiazepoxide unreliable in the treatment of alcohol withdrawal symptoms.
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Reiter et al. (2026) studied this question.
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