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March 7, 2026World Journal of Surgical OncologyOpen Access

Prognostic value of miR-26b-5p in prostate cancer and its regulatory effect on tumor progression

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Authors

CGChao GaoXuzhou Medical CollegeLLLu LouXuzhou Medical CollegeLMLong MiaoXuzhou Medical College

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Overview

This research uncovers the regulatory role of mir-26b-5p in tumor progression in prostate cancer, indicating its potential as a prognostic factor.

Key Points

  • To explore the regulatory mechanism of the miR-26b-5p/ADAM17 pathway in prostate cancer and its prognostic value.
  • Recruited serum samples from 138 prostate cancer patients and 138 healthy controls
  • Quantified mRNA expression using RT-qPCR
  • Conducted dual-luciferase assay to validate interactions
  • Assessed cell proliferation with CCK-8 assay
  • Measured inflammatory cytokine levels using ELISA
  • miR-26b-5p was significantly downregulated in prostate cancer samples
  • Low expression of miR-26b-5p correlated with poor prognosis
  • Overexpression of miR-26b-5p suppressed cell proliferation, migration, and invasion
  • miR-26b-5p overexpression promoted apoptosis and inhibited TNF-α and IL-6 secretion
  • miR-26b-5p targets and suppresses ADAM17 expression

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69abc2075af8044f7a4eb47bhttps://doi.org/10.1186/s12957-026-04228-3
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Also Consider

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  1. 1Circulating Cell-Free miR-25-3p Is Upregulated in Brazilian Patients with Prostate Cancer and Contributes to Tumor Aggressiveness2026
  2. 2Expression and prognostic value of miR-26b-5p in Triple-Negative Breast Cancer (TNBC): Evidence from patient tissues and in silico analysis2025
  3. 3Mendelian randomization reveals causal circulatory microRNAs in prostate cancer pathogenesis and prognosis2025
  4. 4In silico Identification of microRNAs Differentially Expressed in Prostate Cancer and Related to Tumor Aggressiveness2026 · 2 citations
  5. 5Androgen receptor modulatory miR-1271-5p can promote hormone sensitive prostate cancer cell growth2024