A case report reveals refractory severe hypocalcemia in a normo-magnesemic patient using PPIs, suggesting important clinical awareness needs.
Proton pump inhibitors (PPIs) are commonly prescribed drugs to reduce gastric acid secretion and treat a variety of gastrointestinal disorders. Hypomagnesemia has been reported with long-term PPI use. We report a case of long-term PPI use associated with refractory severe hypocalcemia secondary to a normo-magnesemic tissue magnesium deficiency. The patient presented with clinical symptoms of spasms and perioral tingling along with prolongation of QTc interval on electrocardiogram. On failure of intravenous (IV) calcium therapy, the patient improved after a trial of IV magnesium therapy. It is crucial in clinical practice to be aware of adverse events of long-term PPI therapy.
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Sangole et al. (2023) studied this question.
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