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March 7, 2026Applied BiosciencesOpen Access

Formulation by Design: Multiobjective Optimization of a Synergistic Essential Oil Blend with Bioactivities for Skin Healing Applications

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Authors

ABAndres Zapata BetancurFLFreddy Forero LongasADAdriana Pulido Diaz

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Overview

Optimization study reveals effective essential oil blend for skin healing, suggesting promising natural therapies.

Key Points

  • The aim is to optimize a blend of essential oils for enhanced skin healing properties.
  • Analyzed individual essential oil compositions and cytotoxicity.
  • Employed a D-optimal mixture design to assess biological responses.
  • Conducted GC-FID analysis to identify major components and their concentrations.
  • Cinnamon exhibited the highest photoprotective capacity with SPF of 4.5.
  • The optimized blend showed a maximum protection of 98.4% against erythrocyte lysis due to synergistic effects.
  • Highest catalase activity recorded was 160.86 kU/g Hb with specific essential oil mixtures.

Cite This Study

Betancur et al. (2026) studied this question.

synapsesocial.com/papers/69abc2255af8044f7a4eb708https://doi.org/10.3390/applbiosci5010018
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