What question did this study set out to answer?

The research aims to investigate how RAS(ON) inhibition and chemotherapy affect varying cell types in pancreatic cancer.

March 7, 2026Cancer Research

Abstract A017: RAS inhibition and cytotoxic chemotherapy target complementary cell states in pancreatic cancer

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Authors

LTLorenzo Tomassoni ACAlvaro Curiel-GarciaColumbia University Irving Medical Center HGHarika GundlapalliRevolution Medicines (United States)

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Implication

Investigative study shows that RAS inhibition combined with chemotherapy targets diverse malignant cell types in pancreatic cancer, suggesting new treatment approaches.

Key Points

The research aims to investigate how RAS(ON) inhibition and chemotherapy affect varying cell types in pancreatic cancer.
Conducted single cell RNA sequencing on over three dozen PDAC tumors from KPC mice.
Utilized spatial transcriptomics to confirm findings about histological changes.
Employed the OncoTreat algorithm to evaluate susceptibility of cell states to chemotherapy.
Performed preclinical intervention studies with RAS inhibitors and chemotherapy agents.
RAS inhibition significantly depleted poorly differentiated malignant cells in KPC tumors.
Chemotherapy agents primarily targeted well-differentiated malignant cells.
Combination therapies displayed enhanced efficacy in various preclinical models of PDAC.
Promising results indicate a rationale for combining RAS inhibitors with standard chemotherapy.

Cite This Study

Tomassoni et al. (2026) studied this question.

synapsesocial.com/papers/69abc2255af8044f7a4eb7e5 https://doi.org/10.1158/1538-7445.rasoncother26-a017

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Implication

Investigative study shows that RAS inhibition combined with chemotherapy targets diverse malignant cell types in pancreatic cancer, suggesting new treatment approaches.

Abstract A017: RAS inhibition and cytotoxic chemotherapy target complementary cell states in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract A017: RAS inhibition and cytotoxic chemotherapy target complementary cell states in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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