What question did this study set out to answer?

This research aims to examine gene expression changes in Pseudomonas aeruginosa during chronic biofilm infection.

March 7, 2026MicrobiologyOpen Access

Pseudomonas aeruginosa gene expression changes during established biofilm infection in a cystic fibrosis lung model

View Full Paper

Ask AI

Bookmark

Authors

Investigating gene expression changes in established biofilm infections in a lung model, revealing insights into antimicrobial tolerance.

This research aims to examine gene expression changes in Pseudomonas aeruginosa during chronic biofilm infection.
Utilized an ex vivo pig lung model to study Pseudomonas aeruginosa PA14 biofilm over 7 days
Analyzed gene expression at 24 hours, 48 hours, and 7 days post-infection
Investigated tolerance to polymyxins
Compared gene expression to identify key changes associated with biofilm infection
The ex vivo model maintained a stable biofilm population for at least 7 days
Increased antibiotic tolerance was observed in the biofilm
Significant upregulation of sulphur metabolism-related genes was noted
No differential expression of established antimicrobial resistance-associated genes was found

Harrington et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark