Electrochemical Regioselective C(sp ² )–H Selenylation of Pyrrolo[2,3‐ d ]pyrimidine Derivatives With Diselenides

An efficient electrochemical strategy has been established for the direct selenylation of pyrrolo[2,3‐ d ] pyrimidine derivatives employing diselenides as the selenium source. This transformation proceeds under catalyst‐ and oxidant‐free conditions, enabling efficient formation of C( sp 2 )─Se bonds. Moreover, this strategy offers notable advantages including broad substrate scope, good functional group compatibility, high site‐selectivity, and exceptional atom economy. Furthermore, preliminary mechanistic studies suggest that the reaction likely involves radical cation intermediates, which play a key role in promoting the selenylation process.