Key result
GI symptoms frequently accompany pediatric orthostatic intolerance, requiring holistic biopsychosocial care.
Why the study?
Frontline medical professionals need to understand the interplay between orthostatic and gastrointestinal symptoms in autonomic disorders to accurately characterize disorders and guide appropriate testing and management.
Highlights the importance of a holistic biopsychosocial approach to managing concurrent orthostatic and gastrointestinal symptoms in pediatric autonomic dysfunction.
Supports holistic biopsychosocial care for affected children; extends evidence linking gastrointestinal and orthostatic symptoms in pediatric autonomic disorders.
Disorders of the autonomic nervous system commonly present with symptoms of orthostatic intolerance in children and adolescents. These conditions frequently manifest with a combination of orthostatic dizziness and gastrointestinal (GI) symptoms, including pain, nausea, vomiting or regurgitation, changes in bowel habits, or altered nutritional intake, in addition to extraintestinal symptoms (eg, fatigue, joint pains, sleep disturbance) leading to functional impairment. It is necessary for frontline medical professionals to understand the interplay among symptoms within these disorders to more accurately characterize an individual patient's disorder toward appropriate testing and management. Treatment for orthostatic and GI disorders should emphasize a holistic biopsychosocial model of care aimed at addressing patient symptoms, identifying and managing concurrent conditions, supporting nutritional needs along with normal pediatric growth and development, and supporting return to normal physical, mental, and social functioning.
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Osgood et al. (2026) studied this question. Gastrointestinal symptoms frequently co-occur with orthostatic intolerance in pediatric autonomic disorders, requiring holistic biopsychosocial treatment.
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