Multitarget Role of Isotretinoin in Managing Associated Darier Disease and Folliculitis Decalvans

Darier disease (DD) and folliculitis decalvans (FD) are rare coexisting conditions that pose therapeutic challenges. We report a 38-year-old male with DD and FD who achieved lasting control with isotretinoin (20 mg/day) and sulfamethoxazole–trimethoprim after previous treatments provided only temporary relief. Isotretinoin’s anti-inflammatory and keratolytic effects improved both conditions by targeting shared mechanisms and modulating the microbiota. This case highlights isotretinoin’s role as a multitarget therapy for managing DD and FD.