Neutrophil Extracellular Traps and Intestinal Diseases: A Narrative Review.

Neutrophil extracellular traps (NETs) are a network-like structure released by neutrophils into the extracellular space in response to various stimuli, with DNA as the main component, to which histones, granulins, cytoplasmic proteins, and other proteins are attached. Previous studies have shown that NETs are involved in the development of immune diseases, inflammation, tumors, etc. NETs are associated with the development of several intestinal diseases, including inflammatory bowel disease and intestinal ischemia-reperfusion injury. NETs may also interact with microorganisms to contribute to the development of inflammatory bowel disease and participate in the proliferation, metastasis, and thrombosis of colorectal cancer cells. This review comprehensively summarizes the latest research progress on NETs and intestinal diseases, providing a valuable reference for further investigations in this field.