Causal insights reveal a 15-year pre-diagnostic window for glaucoma, highlighting screening performance with predictive utility.
This study reveals a 15-year window of detectable plasma proteomic dysregulation preceding glaucoma diagnosis. The identified causal proteins, particularly LTBP2, provide mechanistic insights and represent potential therapeutic targets. The strong predictive performance demonstrates the translational potential of these findings for risk-stratified screening.
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Zhao et al. (2026) studied this question.
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