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March 8, 2026BMC PediatricsOpen Access

The influencing factors of amplitude-integrated electroencephalography and bilirubin-induced neurological dysfunction scores in neonates with hyperbilirubinemia: a cross-sectional study

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Authors

JCJie ChenLXLiang XiaJWJiaojiao Wu

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Overview

Cross-sectional study shows total bilirubin relates to abnormal aEEG and BIND scores in neonates, indicating bilirubin burden impacts brain function.

Key Points

  • This study analyzes the factors influencing aEEG and BIND scores in neonates diagnosed with hyperbilirubinemia.
  • Cross-sectional analysis of 294 neonates with hyperbilirubinemia
  • Bedside aEEG monitoring and BIND scoring conducted within 48 hours of admission
  • Data collected on clinical parameters and laboratory results
  • Statistical analyses including logistic regression and correlation analysis were performed
  • Indirect bilirubin/albumin ratio significantly associated with abnormal aEEG (OR = 1.722) and BIND scores (OR = 1.251)
  • Area under the ROC curve for IB/A identifying abnormal scores was 0.736 for aEEG and 0.587 for BIND
  • High specificity and low sensitivity observed for cutoff values of IB/A

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69acc57d32b0ef16a404fca7https://doi.org/10.1186/s12887-026-06700-1
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Parthenolide ameliorates bilirubin-induced neuronal cell injury by mediating autophagy2026
  2. 2The impact of perinatal inflammation on the electroencephalogram in preterm infants: a systematic review2022 · 9 citations
  3. 3Etiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong2023 · 15 citations
  4. 4Amplitude-integrated electroencephalography improves the predictive ability of acute bilirubin encephalopathy2021 · 6 citations