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March 8, 2026MicroorganismsOpen Access

A New Challenge of Antibiotic-Resistant Bacteria: Carbapenem-Resistant Enterobacter cloacae Complex in a One Health Perspective

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Authors

HWHuina WangJHJingyi HanYLYong Li

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Overview

This review demonstrates increasing detection of multidrug-resistant Enterobacter cloacae in humans and animals, indicating urgent need for coordinated surveillance.

Key Points

  • To synthesize evidence on the epidemiology and mechanisms of carbapenem-resistant Enterobacter cloacae Complex (CRECC) across human, animal, and environmental domains.
  • Review of epidemiological reports on CRECC detection in healthcare and environmental settings
  • Analysis of resistance genes and plasmid types related to CRECC
  • Assessment of environmental reservoirs influencing resistance dissemination
  • CRECC is increasingly associated with bloodstream infections and pneumonia in healthcare settings
  • Key resistance mechanisms include carbapenemase genes and plasmid-mediated gene transfer
  • Potential epidemiological links exist across human, animal, and environmental sectors, warranting integrated surveillance.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69acc58f32b0ef16a404fd38https://doi.org/10.3390/microorganisms14030594
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