The synthesis demonstrates regioselective formation of selenocyanatoacrylamides in the presence of ammonium chloride, suggesting new pathways for amide compounds.
A regio- and stereoselective synthesis of new vinyl selenocyanates (yields 76–93 %), containing N-alkylamide groups and heterocyclic amide substituents, has been developed based on the reaction of 3-trimethylsilyl-2-propynamides with potassium selenocyanate. The reaction proceeds in the presence of ammonium chloride in aqueous acetonitrile and is accompanied by a desilylation process.
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M. V. Andreev (2025) studied this question.
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