This research demonstrates regioselective C-H bond functionalization in thiophenes, highlighting advances in palladium-catalyzed strategies.
The regioselective functionalization of the C-H bond at the C2-position of 3-substituted thiophenes is challenging, as both thienyl a-positions may be reactive, generally affording mixtures of C2-, C5-and C2,C5-(di)functionalized thiophenes....
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Lan et al. (2025) studied this question.
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