Therapeutic and Adjuvant Effects of Probiotics in the Management of Oral Cancer: A Scoping Review of Preclinical and Clinical Evidence

This protocol outlines a scoping review designed to systematically map the preclinical and clinical evidence on the therapeutic and adjuvant effects of probiotics in the management of oral cancer. The review aims to identify probiotic strains investigated in oral cancer models, summarize their reported antitumor efficacy, mechanisms of action, and safety profiles, and evaluate their potential role as adjunctive agents alongside conventional therapies. By integrating evidence from in vitro, in vivo, and clinical studies, the review seeks to clarify current knowledge gaps and inform future translational research in probiotic-based strategies for oral oncology.