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June 25, 2026Systematic ReviewsOpen Access

Efficacy of probiotics in the management of oral candidiasis: an umbrella review of systematic reviews and meta-analyses

Vini Mehta Cosimo Galletti Ankita Mathur Namrata Suresh Dhruva Nandi Javier Flores-Fraile

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Key Points

This umbrella review aims to assess the effectiveness of probiotics as an adjunct treatment for oral candidiasis.
Conducted comprehensive search across four databases (PubMed, Embase, Scopus, Web of Science) until January 2026.
Included systematic reviews with or without meta-analyses on probiotics' impact on oral Candida spp. count in CFU/mL.
Assessed evidence quality using AMSTAR 2 and GRADE approaches.
3 out of 7 studies (42.8%) had low confidence according to AMSTAR 2; 4 studies (57.1%) rated critically low.
Quality of evidence varied from low to very low across clinical outcomes for different populations.
Current evidence suggests probiotics may assist in OC management but cannot replace traditional treatments.

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Implication

Umbrella review synthesizes evidence on probiotics' effectiveness in treating oral candidiasis, suggesting further research is needed.

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Cite This Study

Mehta et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953f0d2 https://doi.org/10.1186/s13643-026-03249-z

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Keep reading

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