Treatment for massive conjunctival malignant melanoma: Analysis of two cases

Introduction. Conjunctival malignant melanoma (CMM) is a highly malignant tumor. Due to its low incidence, atypical early clinical manifestations, and diverse pathological forms, it is easily misdiagnosed or missed in clinical practice, along with extremely poor prognosis. This study aims to report the treatment outcomes of two cases of massive malignant melanoma of CMM to provide insights into clinical diagnosis and treatment strategies. Case outline. Two cases of massive malignant melanoma of the CMM are reported. Both patients presented to our hospital due to black masses in the eyelid, which were diagnosed as malignant melanoma upon examination. After tumor resection, combined treatment with oral administration of temozolomide capsules and intravenous injection of cisplatin was performed, and no recurrence was observed during 1 year of follow-up. Conclusion. This study suggests that although CMM is rare and has subtle early symptoms, timely diagnosis, thorough surgical resection combined with personalized adjuvant therapy (including chemotherapy, targeted, and immunotherapy) can improve patient prognosis. Enhancing awareness among clinicians and patients, and implementing genetic testing-guided precision treatment, are key to improving therapeutic outcomes.