Islatravir distribution in plasma, peripheral blood mononuclear cells, and mucosal tissues after monthly oral dosing

CW Hendrix; S L Hillier; Linda-Gail Bekker; Sharlaa Badal-Faesen; SA Riddler; Mark A. Marzinke; Edward Fuchs; Pippa Macdonald; Stacey Edick; Ethel D. Weld; C.M. Chavez-Eng; Barbara J. Evans; Xiaowei Zang; Ryan Vargo; Brenda Homony; Katherine Nedrow; Rebeca Plank; Michael Robertson; Prachi Wickremasingha; Munjal Patel

doi:10.1097/qad.0000000000004477

Key Points

This research investigates the distribution of islatravir in various tissues following oral administration.
Examined islatravir distribution in plasma and mucosal tissues after monthly dosing.
Analyzed peripheral blood mononuclear cells for islatravir concentration.
Assessed the pharmacokinetics of islatravir and its active form in different compartments.
Islatravir shows favorable distribution in plasma and tissues.
Tissue distribution supports its evaluation for HIV-1 pre-exposure prophylaxis.
Islatravir-triphosphate levels indicate potential efficacy in preventing HIV-1 infection.

Implication

Monthly oral dosing of islatravir improves tissue distribution for HIV-1 pre-exposure prophylaxis, suggesting its potential as an NRTTI.

Abstract

The favorable tissue distribution of islatravir and islatravir-triphosphate following oral administration supports the evaluation of NRTTIs for HIV-1 pre-exposure prophylaxis.

Discussion

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Cite This Study

Hendrix et al. (2026) studied this question.

synapsesocial.com/papers/69acc59c32b0ef16a40501eb https://doi.org/10.1097/qad.0000000000004477

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Islatravir distribution in plasma, peripheral blood mononuclear cells, and mucosal tissues after monthly oral dosing

Key Points

Implication

Abstract

Discussion

Cite This Study

Islatravir distribution in plasma, peripheral blood mononuclear cells, and mucosal tissues after monthly oral dosing

Key Points

Implication

Abstract

Discussion

Cite This Study

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