Infectious retinitis associated with JAK inhibitors: the ongoing duality of JAK inhibitors

To discuss the recent evidence that Janus kinase (JAK) inhibitors can cause viral retinitis. A commentary on the case report in this issue and a review of cases in the literature. A total of 6 cases have now been reported of cytomegalovirus retinitis associated with Jak inhibitors. Additionally, there was a case of bilateral toxoplasma retinitis and a case of herpetic scleritis. It is important to be aware of the potential blinding complications associated with JAK inhibitors and if the patient complains of acute vision loss and/or floaters, the patient should be emergently referred to a retina specialist.