Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

Amanda C Walls; Adrienne Vaughan; Kartik Balachandran

doi:10.1039/d5lc00978b

January 1, 2026Lab on a Chip

Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

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Key Points

This research aims to develop a model for studying how particulate matter exposure affects inflammation in nasal airways.
Developed a nasal airway-on-chip co-culture model
Examined the response of airway cells to particulate matter exposure
Assessed inflammation markers after exposure to PM
Particulate matter exposure increased inflammation in airway cells
The model can mimic urban air pollution effects on respiratory health
Findings may help elucidate mechanisms behind respiratory diseases linked to PM

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Implication

Co-culture model reveals particulate matter impacts on inflammation in airway cells, suggesting new insights into urban air pollution effects.

Abstract

Particulate matter (PM) is a major component of urban air pollution and is strongly associated with respiratory diseases. However, the mechanisms of PM-induced inflammation remain poorly understood due to a...

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Walls et al. (2026) studied this question.

synapsesocial.com/papers/69acc59c32b0ef16a4050307 https://doi.org/10.1039/d5lc00978b

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Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

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Cite This Study

Development of a nasal airway-on-chip co-culture model to study particulate matter exposure

Key Points

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Implication

Abstract

Discussion

Cite This Study

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