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March 8, 2026

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Cases Secondary to Topical Medications.

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Authors

ECElyssa CheeEHEsther HongTSThomas Stewart

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Overview

Systematic review reveals comparable outcomes for SJS and TEN triggered by topical medications, suggesting clinician awareness is critical.

Key Points

  • To analyze cases of Stevens-Johnson syndrome and toxic epidermal necrolysis triggered by topical medications.
  • Conducted a systematic review of SJS/TEN cases
  • Identified drug culprits, disease characteristics, and outcomes
  • Findings indicate outcomes in SJS/TEN cases from topical medications are comparable to systemic cases
  • Topical formulations can trigger severe reactions such as SJS and TEN, which are typically attributed to systemic medications

Cite This Study

Chee et al. (2026) studied this question.

synapsesocial.com/papers/69acc5b032b0ef16a405038ehttps://doi.org/10.1111/ajd.70078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1WHEN SKIN TURNS AGAINST THE BODY: A CLOSER LOOK AT SJS AND TEN2025
  2. 2Stevens Johnson Syndrome and Toxic Epidermal Necrolysis Updates on Management2024
  3. 3A Systematic Review of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Epidemiology and Treatment Strategies2026
  4. 4Drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis: a 10-year retrospective study of 103 cases2025 · 4 citations
  5. 5Pathogenesis and A Practical Guide to the Management of Steven-Johnson Syndrome & Toxic Epidermal Necrolysis2024