Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 8, 2026Nature CommunicationsOpen Access

Concise construction of β-branched aromatic D-amino acids via transaminase-catalyzed dynamic kinetic resolution

View Full Paper
Ask AI
Bookmark
Share

Authors

ZLZheng LiuQingdao UniversityWZWei ZhaiZZZhihua Zeng

Discussion

Loading...

Member takes

Overview

Asymmetric synthesis achieved high yields of β-branched D-amino acids, indicating their potential in pharmaceuticals.

Key Points

  • The aim is to investigate the efficient synthesis of β-branched aromatic D-amino acids using transaminases.
  • Employ transaminase BsDAAT from Bacillus sp. strain YM-1 for asymmetric synthesis.
  • Utilize dynamic kinetic resolution for effective transamination.
  • Perform enzyme engineering and docking analysis for optimized yields.
  • Achieved high yields up to 99% for β-branched aromatic D-amino acids.
  • Obtained high diastereomeric ratios (>20:1) and enantiomeric excess values (up to 99%).
  • Successfully integrated synthesized D-amino acids into the antineoplastic reagent Lanreotide.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69acc5b032b0ef16a4050423https://doi.org/10.1038/s41467-026-70265-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficient Access to β-Branched Noncanonical Amino Acids via Transaminase-Catalyzed Dynamic Kinetic Resolutions Driven by a Lysine Amine Donor2024 · 1 citations
  2. 2Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron‐Deficient Aromatic <scp>d</scp>‐Amino Acids2025
  3. 3Transaminase-Catalyzed Synthesis of β-Branched Noncanonical Amino Acids Driven by a Lysine Amine Donor2024 · 32 citations
  4. 4Hierarchical Engineering of <i>meso</i>-Diaminopimelate Dehydrogenase for Efficient Synthesis of Bulky <scp>d</scp>-Amino Acids2024 · 12 citations
  5. 5Nickel-Photocatalytic Deoxygenative Arylation toward β-Methyl-Branched α-Amino Acids2026 · 1 citations