Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks.

Timothy Craig; Emel Aygören-Pürsün; Jonathan A Bernstein; Paula J Busse; Teresa Caballero; Danny M Cohn; Mar Guilarte; Henriette Farkas; Douglas H. Jones; Sorena Kiani‐Alikhan; Michael E Manning; M. Maurer; Marc A Riedl; Sinisa Savic; H James Wedner; Patrick F. K. Yong; Andrea Zanichelli; Sally van Kooten; Matthew Iverson; Erik G. Hansen; James Hao; Michael D. Smith; Christopher Yea; Paul K Audhya; William R Lumry

doi:10.1111/cea.70241

Key Points

To assess the impact of oral sebetralstat on anxiety experienced during hereditary angioedema attacks.
Randomised trial comparing sebetralstat treatment with placebo in patients with hereditary angioedema.
Participants experienced moderate-to-extreme anxiety during HAE attacks.
Significant reduction in anxiety was observed in attacks treated with sebetralstat compared to placebo.
Moderate-to-extreme anxiety was common in HAE attacks.

Implication

Randomised trial shows greater anxiety reduction in hereditary angioedema with sebetralstat versus placebo, indicating its potential benefits.

Abstract

Moderate-to-extreme anxiety was common in HAE attacks. Reduction in anxiety was significantly greater in attacks treated with sebetralstat compared with placebo.

Discussion

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Cite This Study

Craig et al. (2026) studied this question.

synapsesocial.com/papers/69acc5b032b0ef16a40504d7 https://doi.org/10.1111/cea.70241

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Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks.

Key Points

Implication

Abstract

Discussion

Cite This Study

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks.

Key Points

Implication

Abstract

Discussion

Cite This Study

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