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March 8, 2026DiseasesOpen Access

Oxidative Stress Biomarkers in Silicosis: A Systematic Review

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Authors

MPMaria Carmina PauEZElisabetta ZinelluBPBarbara Piras

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Overview

Systematic review finds oxidative stress biomarkers indicate increased fibrosis and inflammation in silicosis patients.

Key Points

  • To appraise the evidence on oxidative stress biomarkers in silicosis patients compared to healthy controls.
  • Conducted a systematic literature search in PubMed, Scopus, and Google Scholar
  • Included studies assessing oxidative stress biomarkers in biological samples
  • Compared patients with silicosis against unexposed healthy controls.
  • MDA significantly increased while SOD decreased in silicosis patients
  • Elevated levels of oxidant molecules confirmed lipid, nitrosative, and DNA oxidative damage
  • Antioxidant defenses were compromised, with variation in markers by disease stage.

Cite This Study

Pau et al. (2026) studied this question.

synapsesocial.com/papers/69acc5b032b0ef16a4050504https://doi.org/10.3390/diseases14030098
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Also Consider

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  1. 1Oxidative Stress And Redox-Based Interventions In Chronic Diseases: A Systematic Review2025 · 1 citations
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  3. 3Alterations and associations between lung microbiota and metabolite profiles in silica-induced lung injury2024 · 1 citations
  4. 432 Occupational exposure to respirable crystalline silica and its impact on lipid mediators and oxidative stress markers in blood and urine2026
  5. 5Use of Biochemical Biomarkers to Evaluate the Role of Oxidative Stress in the Progression of COVID-19 Severity2024