Key result
Intensive LDL-C lowering achieves <55 mg/dL targets in ~50% of Japanese ACS patients at four weeks.
Why the study?
Clinical evidence was lacking for lowering LDL-C to <55 mg/dL and the proportion of familial hypercholesterolemia among Japanese ACS patients needed clarification.
Does an intensive LDL-C lowering clinical pathway and FH screening improve the proportion of ACS patients attaining LDL-C <55 mg/dL?
Cohort (n=1,000)
Yes
Does an intensive LDL-C lowering clinical pathway and FH screening improve the proportion of ACS patients attaining LDL-C <55 mg/dL?
This study protocol outlines a multicenter registry to evaluate a clinical pathway targeting LDL-C <55 mg/dL and systematic familial hypercholesterolemia screening in Japanese patients with acute coronary syndrome.
Supports intensive LDL-C pathways in Japanese ACS; extends evidence to real-world cohorts with FH screening.
Background: Acute coronary syndrome (ACS) is the critical situation caused by decreased blood flow of the coronary arteries. The most recent clinical guideline compiled by the Japanese Circulation Society (JCS) recommends lowering low-density lipoprotein cholesterol (LDL-C) to <70 mg/dL in patients with ACS, because of the lack of clinical evidence. It has been shown that there are substantial numbers of patients with familial hypercholesterolemia (FH) among ACS patients. On this basis, we intend assembling a multicenter registry to establish the evidence for lowering LDL-C <55 mg/dL while also clarifying the proportion of FH patients among Japanese ACS patients using a prespecified clinical pathway.
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Tada et al. (2026) conducted a cohort in Acute coronary syndrome (n=1,000). Intensive LDL-C lowering treatment and familial hypercholesterolemia screening clinical pathway was evaluated on Proportion of patients who attain LDL-C <55 mg/dL at 4 weeks. The Hokuriku-plus ACS registry is a prospective study designed to evaluate an intensive LDL-C lowering pathway targeting <55 mg/dL and familial hypercholesterolemia screening in 1,000 Japanese patients with acute coronary syndrome.
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