Population-based follow-up study finds clozapine reduces hospitalization in treatment-resistant schizophrenia, suggesting new treatment strategies.
Clozapine is associated with a substantially lower risk of hospitalisation than other antipsychotics, including LAIAs, in patients with TRS, confirming its superior effectiveness in a real-world setting. The potential benefit of combining clozapine with second-generation LAIAs, particularly in women, suggests a role for stratified treatment strategies and warrants further prospective investigation.
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Zhou et al. (2026) studied this question.
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