Analytical validation of a multiplex mass spectrometry test for coagulation factors indicates feasibility for diagnostics, suggesting future clinical applications.
We developed and validated a QPMS test for multiplexed quantitation of FBG, VWF, FIX, and FXI. Enrichment is required for low-abundant FVIII. This study indicates analytical feasibility for the use of QPMS in diagnostics and justifies development of one QPMS test encompassing all coagulation- and fibrinolysis-related proteins.
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Linthorst et al. (2026) studied this question.
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