Venous Thromboembolism with Combined Oral Contraceptives Based on Estrogen and Progestin Content: A disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database

Lucie Raskin; Marie Didembourg; Jean-Michel DOGNE; Médéa Locquet; Mitchell D. CREININ; Olivier Bruyère; Jonathan DOUXFILS

doi:10.1016/j.ajog.2026.02.046

March 1, 2026American Journal of Obstetrics and GynecologyOpen Access

Venous Thromboembolism with Combined Oral Contraceptives Based on Estrogen and Progestin Content: A disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database

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Key Points

This research aims to compare the rates of venous thromboembolism associated with different combined oral contraceptives based on their estrogen and progestin content.
Disproportionality analysis of Adverse Event Reporting System database
Comparison of reports for combined oral contraceptives containing estetrol, 17β-estradiol, and ethinyl estradiol
Assessment of thrombotic events across different contraceptives
Body-identical estrogen contraceptives show lower venous thromboembolism reports compared to EE-based pills
Rates of venous thromboembolism are similar between body-identical estrogen contraceptives and progestin-only pills
Findings indicate a potentially safer thrombotic profile for body-identical estrogen-containing contraceptives

Implication

Analysis reveals lower venous thromboembolism rates in estrogen-based contraceptives, suggesting a safer profile.

Abstract

Combined oral contraceptives containing body-identical estrogens, estetrol, and 17β-estradiol, have lower proportions of venous thromboembolism reports than EE-based pills and are similar to progestin-only pills. These findings suggest a potentially safer thrombotic profile of body-identical estrogen-based combined oral contraceptives.

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Cite This Study

Raskin et al. (2026) studied this question.

synapsesocial.com/papers/69ada804bc08abd80d5bb21d https://doi.org/10.1016/j.ajog.2026.02.046

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Venous Thromboembolism with Combined Oral Contraceptives Based on Estrogen and Progestin Content: A disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database

Key Points

Implication

Abstract

Discussion

Cite This Study

Venous Thromboembolism with Combined Oral Contraceptives Based on Estrogen and Progestin Content: A disproportionality analysis of the United States Food and Drug Administration Adverse Event Reporting System database

Key Points

Implication

Abstract

Discussion

Cite This Study

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