Systematic review shows important liver disease in children with Alpha-1 Antitrypsin Deficiency, indicating need for better monitoring.
Clinically important liver disease occurs in a substantial subset of children with Pi*ZZ A1ATD. Declining rates of elevated liver enzymes with age should not be interpreted as disease resolution. Standardized registries are needed for longitudinal surveillance, to identify disease modifiers, and to guide early intervention in this high-risk population.
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Syanda et al. (2026) studied this question.
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