Systematic review finds sugammadex reduces postoperative delirium in surgical patients, suggesting it's a preferable option.
Sugammadex is associated with a reduced incidence of POD compared to neostigmine, particularly within the 1st 24 hours after surgery, based on consistent findings from RCTs. This benefit was not observed in NRCTs. Further well-designed RCTs using standardized delirium assessments are required.
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Kwak et al. (2026) studied this question.
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