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March 8, 2026Proceedings of the National Academy of SciencesOpen Access

DNA methylation in invertebrate genomes and cell lineage plasticity

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Authors

LHLaurel S. HiebertUniversity of ViennaSYSoojin V. Yi

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Overview

Comparative analysis reveals that higher DNA methylation correlates with enhanced regenerative capacities in invertebrates, suggesting evolutionary implications.

Key Points

  • The study aims to explore how DNA methylation varies across invertebrate genomes and its implications for cell lineage plasticity.
  • Conducted phylogenetic comparative analysis of 175 invertebrate species across 14 phyla.
  • Analyzed genome-wide levels of CpG methylation and its association with regenerative traits.
  • Assessed the relationship between DNA methylation and cellular behaviors in diverse taxa.
  • Species with greater regenerative capacities showed higher levels of genome-wide CpG methylation.
  • The relationship between DNA methylation and regenerative traits was independent of phylogenetic relatedness.
  • Findings suggest that increased genomic methylation may enhance somatic lineage renewal and plasticity.

Cite This Study

Hiebert et al. (2026) studied this question.

synapsesocial.com/papers/69ada892bc08abd80d5bbae1https://doi.org/10.1073/pnas.2510416123
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