Explores genetic and inflammatory aspects of hidradenitis suppurativa, indicating connections to autoimmune conditions.
Our findings support a dual model of HS pathogenesis involving genetically driven epithelial dysfunction and systemic inflammation. The identification of HLA-DRA-associated variants raises the possibility that HS may share features with autoimmune diseases, while the proteomic profile dominated by innate cytokines suggests that an autoinflammatory component is also involved.
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Argyropoulou et al. (2026) studied this question.
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