What question did this study set out to answer?

To investigate the association between gut microbiota composition and cardiometabolic outcomes over time in a multi-ethnic cohort.

Specific gut microbes are associated with the incidence of cardiometabolic disease in the HELIUS cohort

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Prospective study links gut microbiota to cardiometabolic disease in a diverse cohort, suggesting gut health's importance.

To investigate the association between gut microbiota composition and cardiometabolic outcomes over time in a multi-ethnic cohort.
Conducted a longitudinal study with fecal sample collection from 4792 participants.
Analyzed samples using 16S rRNA sequencing.
Assessed new diagnoses of hypertension, dyslipidemia, diabetes, and major adverse cardiovascular events (MACE).
Utilized logistic and Cox regression analyses to evaluate associations.
129 participants (2.7%) experienced MACE and 180 (3.8%) experienced MACE+ during follow-up.
Higher levels of Eubacterium xylanophilum group spp. and Akkermansia muciniphila correlated with lower MACE+ risk.
Ruminococcus gnavus group spp. was associated with increased MACE risk.
Only Eubacterium xylanophilum group spp. remained significantly associated after adjustments.

Verhaar et al. (2026) studied this question.

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