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March 8, 2026Applied SciencesOpen Access

Molecular Testing in Early Diagnosis and Clinical Assessment of Alzheimer’s Disease: A Narrative Review

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Authors

ZRZuzanna RogaczWPWiktoria PacułaBSBarbara Strzałka-Mrozik

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Overview

Narrative review highlights the role of molecular diagnostics in diagnosing Alzheimer’s disease, indicating the need for better clinical integration.

Key Points

  • The aim is to assess the evolving role of molecular testing in the early diagnosis and clinical evaluation of Alzheimer’s disease.
  • Review of current molecular diagnostic techniques and biomarkers for Alzheimer's disease.
  • Evaluation of cerebrospinal fluid and blood-based biomarker advancements.
  • Analysis of imaging methods like positron emission tomography in diagnostics.
  • Discussion on challenges in clinical implementation and standardization.
  • Molecular diagnostics improve early detection and monitoring of Alzheimer’s disease.
  • Cerebrospinal fluid biomarkers such as amyloid-β and tau are pivotal for diagnosis.
  • Blood biomarkers are gaining traction due to their less invasive nature.
  • Clinical integration is hindered by variability and lack of standardized practices.

Cite This Study

Rogacz et al. (2026) studied this question.

synapsesocial.com/papers/69ada8c2bc08abd80d5bc07ahttps://doi.org/10.3390/app16052554
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Current Status and Future Perspectives of Biomarkers in Alzheimer's Disease Diagnosis].2025
  2. 2Potential diagnostic markers in Alzheimer's disease: current perspectives and future directions2025 · 5 citations
  3. 3From Better Diagnostics to Earlier Treatment: The Rapidly Evolving Alzheimer’s Disease Landscape2025 · 5 citations
  4. 4The Role of Blood-Based Biomarkers in Transforming Alzheimer’s Disease Research and Clinical Management: A Review2025 · 18 citations
  5. 5From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer’s Disease2025 · 11 citations