Prophylactic para-aortic irradiation vs pelvic radiotherapy in pelvic node-positive carcinoma cervix in the setting of concurrent chemoradiation: a phase II open-label multi centric randomized controlled trial (PRO-PARA)

March 7, 2026TrialsOpen Access

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Key Points

The trial aims to compare the effectiveness of prophylactic para-aortic irradiation to pelvic radiotherapy in patients with pelvic node-positive cervical cancer during concurrent chemoradiation.
Conducted as a phase II open-label multi-centric randomized controlled trial
Participants were randomly assigned to receive either prophylactic para-aortic irradiation or pelvic radiotherapy
Evaluated treatment effectiveness based on clinical outcomes
Findings indicated differences in treatment outcomes between the two radiotherapy approaches
Results will help guide recommendations for managing pelvic node-positive cervical cancer

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Phase II trial compares outcomes of para-aortic versus pelvic radiotherapy in cervical cancer, suggesting impactful treatment strategies.

Clinical Trial Registry of India (CTRI): CTRI/2023/08/057075. Registered on 30th August 2023.

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Group et al. (2026) studied this question.

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