PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 8, 2026

Stereoselective Synthesis of Indoline-Fused Cyclobutanes via Dual Functionalization of Alkynyl Diazo Carboxylates.

View Full Paper
Ask AI
Bookmark
Share

Authors

PSPragati SharmaASAkashdeep SharmaNJNishant Joon

Discussion

Loading...

Member takes

Overview

Research demonstrates the synthesis of indoline-fused cyclobutanes, indicating new synthetic pathways for organic compounds.

Key Points

  • This research aims to develop a stereoselective method for synthesizing indoline-fused cyclobutanes.
  • Utilized alkynyl diazoacetates for dual functionalization.
  • Employed Rh-catalyzed insertion of alkynyl carbenes into 2-alkenyl anilines.
  • Conducted base-promoted isomerization and cycloaddition cascade.
  • Achieved yields up to 97%.
  • Obtained excellent stereoselectivity with a ratio greater than 20:1.
  • Expanded the utility of alkynyl diazoacetates for creating diverse indoline-fused cyclobutanes.

Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/69ada8cfbc08abd80d5bc2b9https://doi.org/10.1021/acs.orglett.6c00601
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rhodium(II)-Catalyzed Alkynyl Carbene Insertion into N–H Bonds2024 · 6 citations
  2. 2Accessing SuFExable Cyclobutane‐Fused Indolines via Photocatalytic Intermolecular [2+2] Cycloaddition of Indoles2024 · 15 citations
  3. 3Doyle–Kirmse Reaction on Alkynyl Hydrazone Carboxylates: Synthesis of 1,4-Allenyne and 1,5-Enyne Thioaryl Carboxylates2024 · 8 citations
  4. 4Modern Organic Synthesis with α-Diazocarbonyl Compounds2015 · 1,602 citations
  5. 5Rh-Catalyzed [2,3]-Sigmatropic Rearrangement of Alkynyl Carbenes with Allyl Sulfides to Access Sulfide-Substituted 1,5-Enynes2023 · 8 citations