August 13, 2025

Divergent Synthesis of Pyrrolizine- and Indolizine-Fused Heterocycles via Pd(II)-Catalyzed Cascade Transformation of Functionalized Alkynes.

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MAIN FINDING: A palladium(II)-catalyzed synthesis of pyrrolizine and indolizine heterocycles was achieved with yields up to 84%.
KEY EVIDENCE: The cascade transformation involved intramolecular carboxypalladation followed by σ-vinylpalladium species trapping.
APPROACH: The method used multifunctional alkynes and adjusted conditions for optimal regioselectivity and substrate scope.
SIGNIFICANCE: This process enhances the diversity of heterocycles, crucial for pharmaceutical applications and materials science.

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Pd(II)-catalyzed cascade transforms internal alkynes into pyrrolizine and indolizine heterocycles, indicating good yield and regioselectivity.

Jandial et al. (2025) studied this question.

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Pd(II)-catalyzed cascade transforms internal alkynes into pyrrolizine and indolizine heterocycles, indicating good yield and regioselectivity.