Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database

Keeirah Hiertika Raguram; Manroop Sidhu; Mohammad Ali Omrani; Bala Swetha Baskaran; Niaz Chalabianloo; Manik Chhabra; Hugues Sampasa‐Kanyinga; Flory T. Muanda

doi:10.1093/jac/dkag083

February 23, 2026Journal of Antimicrobial ChemotherapyOpen Access

Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database

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Key Points

To investigate the association between fluoroquinolones and panic attacks using adverse event reports.
Conducted a systematic review of existing literature
Performed a disproportionality analysis using the FAERS database
Analyzed individual case safety reports of adverse events
Found an association suggesting increased panic attack risk with fluoroquinolone use
Emphasized the need for validation through further pharmacoepidemiological studies
Highlighted limitations in determining causal relationships due to reliance on spontaneous reports

Implication

Systematic review finds fluoroquinolones may increase panic attacks risk, suggesting more research is needed.

Abstract

The findings suggest an association between fluoroquinolones and increased risk of panic attacks, underscoring the need for validation through pharmacoepidemiological studies. Due to reliance on spontaneous reports, causal relationships cannot be determined for clinical recommendations. These results offer insights for research on CNS safety profiles of fluoroquinolones.

Discussion

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Cite This Study

Raguram et al. (2026) studied this question.

synapsesocial.com/papers/69ada8dfbc08abd80d5bc4c7 https://doi.org/10.1093/jac/dkag083

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Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database

Key Points

Implication

Abstract

Discussion

Cite This Study

Fluoroquinolones and the risk of panic attacks: a systematic review and disproportionality analysis using individual case safety reports from the FDA Adverse Event Reporting System (FAERS) database

Key Points

Implication

Abstract

Discussion

Cite This Study

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