Early Multimodal Assessment for Prediction of Cerebral Palsy in Neonatal Hypoxic-Ischemic Encephalopathy

aEEG emerged as a robust and independent early biomarker for CP prediction after HIE. Combining aEEG with MRI substantially enhanced diagnostic precision, reflecting complementary functional and structural brain injury mechanisms. Although HNNE and GMA add screening value, they are insufficient alone. Standardized multimodal protocols integrating structural (MRI), functional (aEEG), and clinical (HNNE-GMA) assessments should be incorporated into clinical practice to improve early prognostication and guide neuroprotective interventions.