Real-world effectiveness of sequential pneumococcal vaccination in older adults: a cohort study

Key Points

• This study aims to evaluate the real-world effectiveness of sequential pneumococcal vaccination in reducing disease risk in older adults.
• Conducted a population-based cohort study
• Analyzed outcomes after vaccination with PCV-13 followed by PPSV-23
• Measured incidences of pneumococcal disease, pneumonia, and all-cause mortality
• Sequential vaccination was linked to a lower risk of pneumococcal-related disease
• Associated with reduced incidence of pneumonia and overall mortality
• Findings support current vaccination recommendations for older adults