Obstructive sleep apnea severity, Alzheimer's disease plasma markers, and CSF brain amyloidosis and tau pathology.
Key Points
This research investigates the relationship between obstructive sleep apnea severity and Alzheimer’s disease plasma markers and CSF pathology.
Analyzed plasma Aβ levels and CSF indicators of amyloidosis and tau pathology.
Evaluated the relationship between obstructive sleep apnea severity and biomarkers.
Combined measures of plasma and OSA to enhance detection of Alzheimer’s disease associations.
OSA severity corresponds with elevated plasma Aβ levels.
Combined plasma and CSF measures reveal associations with tau and neurofilament light chain (NfL).
Findings suggest non-invasive methods for identifying Alzheimer’s pathology.
Abstract
OSA severity relates to elevated plasma Aβ and, with CSF amyloid, to tau/NfL. Combined plasma and OSA measures aid non-invasive AD associations' detection.