What question did this study set out to answer?

The aim is to establish a reliable noninvasive diagnostic method for cardiac ATTR amyloidosis without histology.

April 23, 2016Circulation1,919 citationsOpen Access

Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis

JGJulian D. GillmoreBoston University MMMatthew J. MaurerGeneral Cardiology RFRodney H. FalkHeart Failure & Transplant

Key Points

The aim is to establish a reliable noninvasive diagnostic method for cardiac ATTR amyloidosis without histology.
Utilized bone scintigraphy for diagnosis.
Developed noninvasive diagnostic criteria.
Focused on patients without monoclonal gammopathy.
Diagnosis made reliably without histology.
Criteria applicable to the majority of ATTR amyloidosis patients.
Improved diagnosis may enhance patient outcomes.

Abstract

Bone scintigraphy enables the diagnosis of cardiac ATTR amyloidosis to be made reliably without the need for histology in patients who do not have a monoclonal gammopathy. We propose noninvasive diagnostic criteria for cardiac ATTR amyloidosis that are applicable to the majority of patients with this disease.

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