Randomized trial demonstrates higher reperfusion and better functional outcomes with tenecteplase versus alteplase before thrombectomy in ischemic stroke, indicating improved thrombolytic efficacy.
Tenecteplase before thrombectomy was associated with a higher incidence of reperfusion and better functional outcome than alteplase among patients with ischemic stroke treated within 4.5 hours after symptom onset. (Funded by the National Health and Medical Research Council of Australia and others; EXTEND-IA TNK ClinicalTrials.gov number, NCT02388061 .).
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Campbell et al. (2018) studied this question.
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