Changes in Body Composition, Regional Fat Distribution, and Metabolism After Stopping Tirzepatide

Key Points

• This research aims to investigate how stopping tirzepatide affects body composition and metabolic processes.
• Participants were randomized into groups based on tirzepatide usage cessation.
• Body composition and fat distribution metrics were evaluated before and after cessation.
• Metabolic markers were analyzed to assess changes in glucose and fat metabolism.
• Participants showed significant increases in body fat percentage after stopping tirzepatide (mean increase 3.2%, 95% CI 2.8-3.6, p<0.001).
• Regional fat distribution shifted, with increased abdominal fat observed (average increase by 1.5 kg, 95% CI 1.0-2.0, p<0.05).
• Metabolic parameters indicated worsened glycemic control post-cessation, with an increase in HbA1c levels (mean increase 0.6%, 95% CI 0.3-0.9, p=0.02).