In their study, Chen et al 1 examined the association between apolipoprotein E (APOE) genotype and longitudinal cognitive trajectories among middle-aged and older East Asian adults participating in the Healthy Aging Longitudinal Study of Taiwan (HALST).Although sporadic late-onset Alzheimer disease (AD) is polygenic, APOE remains the strongest genetic determinant of AD risk, with carriers of the APOE 4 allele having increased odds of developing AD dementia in a dose-dependent manner compared with APOE 3 homozygotes.Importantly, the magnitude of this association varies by genetic ancestry, with the strongest effects observed in East Asian populations, followed by European populations, and weaker associations in African and Amerindian populations. 2e HALST is a longitudinal study initially enrolling more than 5000 community-dwelling adults aged 55 years or older from 7 regions in Taiwan, encompassing rural and urban settings, multiple ethnic groups and dialects, and a wide range of socioeconomic backgrounds, including educational
Qian et al. (Fri,) studied this question.