Preemptive analgesia improves neurocognitive function in aged mild cognitive impairment rats, indicating potential pain management benefits.
Perioperative preemptive analgesia effectively reduces postoperative pain and improves neurocognitive function in aged MCI rats, via a mechanism linked to maintaining hippocampal GABAA receptor α1/α5 subunit balance and ameliorating hippocampal neural dysfunction. This study provides foundational evidence for clinical postoperative pain management and cognitive protection in elderly MCI patients.
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Ren et al. (2026) studied this question.
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