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March 10, 2026Cell Reports4 citationsOpen Access

ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanisms

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HSHeegwon ShinTDTyler J. DorrityJAJustin Aruda

Key Points

  • The aim is to understand how ADAR1 regulates the formation of dsRNA in both nuclear and mitochondrial transcripts.
  • Characterization of ADAR1's role in dsRNA formation
  • Analysis of editing-dependent mechanisms
  • Examination of editing-independent mechanisms
  • Comparison of nuclear and mitochondrial transcript influences
  • ADAR1 alters dsRNA levels in nuclear transcripts
  • ADAR1 affects mitochondrial transcript formation
  • Both editing-dependent and editing-independent processes are involved
  • Mechanisms differ between nuclear and mitochondrial contexts

Abstract

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

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Cite This Study

Shin et al. (2026) studied this question.

synapsesocial.com/papers/69af947370916d39fea4b715https://doi.org/10.1016/j.celrep.2026.117026
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